Signals Across The Synapse While transmission of a signal along an axon is electrical, transmission between neurons is chemical. The chemicals used to signal are known as neurotransmitters, and the neuron synthesizes them in the axon terminals. Neurotransmitters There are about a hundred chemicals that are either confirmed or suspected neurotransmitters. Most fall into the following categories: Amino acids Modified amino acids/monoamines Includes serotonin, dopamine, norepinephrine, ephinephrine Neuropeptides, which are chains of amino acids Includes endorphins Purines Gases Neurons make most neurotransmitters by modifying amino acids. For example, catecholamines, which includes dopamine, epinephrine, and norepinephrine, are made by attaching a catechol group to an amine group. These three all come from phenylanine. Serotonin comes from tryptophan (found in soy). We get these amino acids from our diet. Neurons keep supplies of neurotransmitters in t...